NO!

i HATE to think of the possibility, but which other couple is there?

That's the only possible thing in my mind :P That way,they can bring them back together for the series finale ♥

we know wilson and sam have split as to the 2nd couple i dont think its huddy i mean thats to obvious my take it could be taub and his wife after last years spoilers i tend not to trust ausellio spoilers

by "at least two" doesn't it mean that there's a possibility that there will be 3 break ups?

Rachel/Taub & Sam/Wilson

Interesting comments...just a few thoughts to toss in the mix...

(H)ouse break-up review: House & Stacy, Chase & Cameron, 13 & Foreman, Cuddy & Lucas, Wilson & Sam & Bonnie & Julie & Sam & my guess for next split..Taub & Rachel.

I don't think breaking up Huddy would be that interesting...almost too predictable.
It would be more interesting if they keep "weaving" them into the show as they build to either a very unique (happy) couple of misfits or a very tragic (death) end...no "middle ground." Zzzz. House doesn't like middle ground.

i say the second big break up is going to be taub and rachel....Huddy might have fights and minor seperations but they won't brak up this season

Couldn't agree more with bluehue comment about them weaving them into the show more for either a odd and unique happy ending or a very tragic and complicated death end otherwise it wouldn't do just to the couple or the show

I don't care who's break-up is coming next. But it's definitely NOT Huddy!
But I did care about Wilson & Sam. It was STUPID break-up! The STUPIDIEST break-up ever!!!! I'm so angry at the authors!!! They were so happy and then sbfdafbsaapw "break-up" it was SO stupid!!! I hate when things go stupid.
Yes, Taub and Rachel maybe, but NOT Huddy!!! I'm pretty sure in this! <3