Over the years, there have been plenty of Spider-Man films. Because of that, there have been several villains that have posed a serious challenge to Spidey. This list is to highlight all of the live-action villains that have opposed the iconic web swinger.

Willem Dafoe became the first actor to play a classic Spider-Man in 2002's Spider-Man. He played the Green Goblin in that film. He had cameo appearances in 2004's Spider-Man 2 and 2007's Spider-Man 3. In 2021, he returned to the role in Spider-Man: No Way Home.

Alfred Molina played Doctor Octopus in Spider-Man 2 and Spider-Man: No Way Home....