Two men named Professor Kevin and Professor Jeff were frustrated. It was a different dimension now and the Powerpuff girls were dead because the evil "Harmony" killed them. The Professors decided to make 5 little girls to fight crime and be the new superheros of Townsville. The concoction worked but it was strong. The concoction exploded which killed the professors. They laid dead on the ground. Later on a lady walked in and saw the professors were dead and she also saw something else... a girl sitting on a mesa, tabela asleep. But where were the other 4? She took the little girl início and tucked her in bed.