I think of Knocked Up... and then, when I think a little deeper, the Man-O-Lantern scene from The 40-Year Old Virgin pops up. =P

Yeah, I get some Knocked Up too!

i think of a line from knocked up 'you hear that, he wants to REAR your child' me and my friend died for a week it was tha funny !

Its "link" for me. Probably most often his reaction to link...

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the first things that pops up in my mind when hearing seth rogen is seeing his ass from knocked up

It's changed, for me.

When I hear "Seth Rogen", my immediate reaction is, "I'm fucking..."
(because of link video with him & Elizabeth Banks XD)

Definitely Freaks and Geeks. He was absolutely awesome on that show (as was everyone else involved).