When the Cullens leave in New Moon, Alice doesn't say goodbye to Bella in order to make a clean break. She later comes back because she thinks that Bella has committed suicide, but in reality, Bella was just cliff diving. She tells Bella what the Cullens have been up to and finds out how hard it was for Bella when they all left her. When Jacob Black tells Edward (thinking that he was Carlisle talking to him on the phone) that Charlie is "at the funeral", Edward thinks he meant Bella's funeral, though he was actually referring to Harry Clearwater's. Alice sees this and she helps Bella get to Volterra, Italy to stop Edward from exposing himself to the world and being killed por the Volturi. She later votes in favor of Bella becoming a vampire. Carlisle is the one chosen to change Bella, because Alice decides that she can't. Bella is trying to get Edward to change her, but Edward disapproves.

Alice is a very friendly person and she shares many of the physical traits associated with Twilight vampires, such as inhuman beauty, pale skin, golden eyes (which darken as thirst increases) and deep purple shadows under her eyes. She is described as being petite, the shortest of the Cullens at 4'10", "thin in the extreme", with small, "pixie-like" features. She is also described to have large eyes and long, delicate eyebrows. Her hair is described as cropped short, spiky, and deep black. She moves gracefully, continually cited as dancing, with a carriage that would "break any ballerina's heart", as described por Bella in Twilight.